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Devil's Claw Root Extract Harpagoside

Product Name:Devil's Claw Root Extract Harpagoside
Synonyms:Grapple Plant,Wood Spider,Harpago
Specification:Standardized as Harpagoside
Phone:86 (0371) 5502 7219

Product Name
Devil's Claw Root Powder Extract
Botanical Name
Harpagophytum procumbens
Standardized as Harpagoside
Grapple Plant, Wood Spider, Harpago
Brown Yellow Fine Powder
Part of Used
Main Benefits
Anti-inflammatory, Antioxidant etc
Applied industries
Dietary supplement, Medicine

Devil's Claw Reviews
Devil’s claw belongs to the Pedaliaceae family and is also known as grapple plant, wood spider, and harpago. It is native to the southern part of the African continent and may be found in the Kalahari Sands of Namibia, Botswana, South Africa, Angola, Zambia, and Zimbabwe. Historically, Harpagophytum procumbens (devil’s claw) has been used as an analgesic, a remedy for fevers and allergies, and as a bitter by San bushmen in Africa to stimulate gastric enzymes and digestion. The British Herbal Pharmacopoeia recommends devil’s claw as a diuretic and sedative, and the German Commission E, the German counterpart to the U.S. Food and Drug Administration, approves devil’s claw for dyspepsia, appetite stimulation, and degenerative disorders of the musculoskeletal system. Devil’s claw has also been used for liver and kidney disorders, as a purgative, an oxytocic, and as a topical agent to treat wounds and skin rashes. Clinical research has shown it to be effective for arthritis and rheumatic disorders.
Chemical constitution of Devil's Claw
The major chemical constituents of Harpagophytum are iridoid glycosides (primarily harpagoside, harpagide, and procumbide), sugars (mainly the tetrasaccharide, stachyose), triterpenoids (oleanolic and ursolic acid), phytosterols (primarily beta-sitosterol), aromatic acids (caffeic, cinnamic, and chlorogenic acids), and flavonoids such as luteolin and kaempferol.6 Harpagoside, harpagide, and procumbide, found in the tubers of the plant, appear to be the most therapeutically important constituents. Secondary storage tubers contain twice as much harpagoside as the tap root. All extracts are not equally effective; whole-plant extracts appear to have a better therapeutic effect than those prepared from isolated parts.  A review of clinical trials utilizing H. procumbens preparations for the treatment of joint and lower back pain found studies utilizing extracts containing 50-60 mg harpagoside daily gave more reliable data and were more effective at alleviating pain and improving mobility than extracts with lower amounts.
Health Benefits of Devil's Claw Powder Extract
Although researches on the health benefits of taking Devil's Claw Powder Extract are limited, some studies suggest that Devil's Claw Powder Extract may offer certain health benefits. Here's a look at several key study findings:
A dried aqueous extract of devil’s claw has been shown to exert a significant dose-dependent analgesic
and anti-inflammatory effect in rats at 5 and 10 mg/kg. However, carrageenan-induced paw edema was not affected by the isolated harpagoside constituent, suggesting harpagoside may not have an anti-inflammatory effect, at least in the doses used in this animal model of inflammation. This suggests that other devil’s claw constituents may be responsible for the anti-inflammatory effect.
Harpagoside appears to exert a peripheral analgesic effect. Human research has demonstrated decreased pain in knee and hip osteoarthritis and nonspecific low-back pain after ingestion of devil’s claw extracts containing harpagoside. Although the mechanism behind this effect has not yet been determined, it is thought to be closely connected to its anti-inflammatory properties.
Animal research has demonstrated a significant antioxidant effect for devil’s claw extract when administered intra-peritoneally to rats. Dose-dependent increases in superoxide dismutase, catalase, and glutathione peroxidase were observed in rat brain tissue and a reduction in lipid peroxidation was also noted. The antioxidant properties may be partially responsible for the anti-inflammatory effect of devil’s claw extracts. The flavonoids (proven scavengers of free radicals) and plant phenols (hydrogen donors and oxygen radical neutralizers) present in devil’s claw extracts may be the constituents responsible for the observed antioxidant activity.
Digestive Aid
The “bitter” action of devil’s claw provided by the iridoid glycosides increases gastric acid production
and stimulates digestion.
Harpagophytum is chondroprotective, possibly due to inhibition of inflammatory mediators, including
COX-2, leukotrienes, nitric oxide, tumor necrosis factor-alpha (TNF-α), and interleukin-1β. In addition,
matrix metalloproteinases and elastase that play key roles in cartilage degradation are inhibited.
Devil's Claw Powder Extract Side Effects
Extracts of H. procumbens appear to be safe when used in appropriate dosages. Side effects are few and usually limited to gastrointestinal upset. Harpagoside has been found to be of low toxicity with an LD50 >13.5 g/kg in mice.31 In a review of 28 clinical trials of devil’s claw extracts, adverse events occurred at a rate of about three percent and did not exceed the rate of those experienced with placebo. Long-term use appears to be safe and without toxicity.
Patients with duodenal ulcers should probably avoid using devil’s claw due to its effect on gastric pH. Because of reported oxytocic properties, devil’s claw extracts are contraindicated during pregnancy.
Devil's Claw Powder Extract Dosage
Devil’s claw extracts can be administered in several forms; dosage varies with each, depending on concentration of active constituents present. The following are typical dosages used historically and clinically. Dried Root: 0.5-1.0 g dissolved in water given orally three times daily for appetite stimulation and stomach upset. Dried root powder (tablet or capsule): 1,800-2,400 mg (50-100 mg harpagoside) daily for arthritis and musculoskeletal pain and inflammation. Crude aqueous root extract: 2-9 g daily for
low-back pain and osteoarthritis.
Where to buy high quality Devil's Claw Root Powder Extract
Henan Steeda Industrial Co.,Ltd (Tiny Grass Botanicals Co.,Ltd) is a manufacturer of botanical extract and experienced supplier of Amino Acids & its Derivatives, Vitamins & its Derivatives, Sweeteners,  Minerals, Sports Nutrition, Nootropics and Cosmetic Ingredients. Devil's Claw Root Powder Extract is one of our most competitive products with stocks available all year round. By providing superior quality, we establish long-term relationships with our clients.

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