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Giant Knotweed Root Extract Polydatin

Product Name:Giant Knotweed Root Extract Polydatin
Synonyms:Piceid,Cis-piceid,trans-piceid
Specification:Standardized as Polydatin
Phone:86 (0371) 5502 7219
Email:info@tgbotanicals.com

Product Name
Giant Knotweed Powder Extract Polydatin
Botanical Name
Polygonum cuspidatum Sieb.
Specification
Standardized as Polydatin
Synonyms
Piceid
Appearance
Off white fine Powder
Part of Used
Root
Main Benefits
Antioxidant etc
Applied industries
Dietary supplement, Medicine

Polydatin Reviews
Polydatin, according to Wikipedia, also named piceid, is one of the active compounds isolated from the Polygonum cuspidatum Sieb. It also could be extracted from grape, peanut, hop cones, red wines, hop pellets, cocoa-containing products, chocolate products and many other daily diets. A great number of pharmacological and pharmacokinetic investigations in the past decades have demonstrated that Polydatin has favorable therapeutic properties, indicating its potential as an effective material.
Comparisons between Resveratrol and Polydatin
Polydatin is a precursor of resveratrol. Look at the figure as below:
2.jpg

The average content of polydatin was found ten times higher than that of resveratrol in the Polygonum cuspidatum.
In vitro researches indicate that resveratrol has chemoprevention effects against cardiovascular diseases, aging, and cancer, however, The oral bioavailability of resveratrol is extremely low due to rapid and extensive metabolism and the consequent formation of various metabolites such as resveratrol-glucuronides and resveratrolsulfates.
Compared with resveratrol, polydatin has a better oral bioavailability than resveratrol. polydatin is the most abundant form of resveratrol in nature. A number of studies have suggested that polydatin, like resveratrol, may have the similar bioactivities such as anticarcinogenic effects, inhibition of platelet aggregation, and antioxidation activity. Recently, it is found that both polydatin and resveratrol have antiinflammatory activity.

Health Benefits of Polydatin
Although researches on the health benefits of taking Polydatin are limited, some studies suggest that Polydatin may offer certain health benefits. Here's a look at several key study findings:
Lung Cancer Treatment 
According to some researchers, Polydatin inhibits growth of lung cancer cells by inducing apoptosis and causing cell cycle arrest. In their studies, thiazolyl blue tetrazolium bromide assay was used to evaluate the inhibitory effect of PD on cell growth. Cell cycle distribution and apoptosis were investigated by flow cytometry. In addition, the expression of several proteins associated with apoptosis and cell cycle were analyzed by western blot analysis. The results demonstrated that PD significantly inhibits the proliferation of A549 and NCI‑H1975 lung cancer cell lines and causes dose‑dependent apoptosis. Cell cycle analysis revealed that PD induces S phase cell cycle arrest. Western blot analysis showed that the expression of Bcl‑2 decreased as that of Bax increased, and the expression of cyclin D1 was also suppressed. The results suggest that PD has potential therapeutic applications in the treatment of lung cancer.
Allergic Diseases Treatment
According to other researchers, Polydatin could attenuate food allergy via store-operated calcium channels in mast cell. In their studies, they established ovalbumin (OVA)-induced food allergic models and evaluated the therapeutic effect of PD on food allergy. Furthermore, they explored the effect of PD on mast cell degranulation and found that the underlying mechanism was related to Ca2+ mobilization. Our research presented here revealed that PD can inhibit food allergy by suppressing mast cell degranulation via regulation of SOCs.
Anti-inflammatory Properties
Polydatin has also been claimed its anti-inflammatory properties by scientists. through their studies, they found polydatin could promote the production of Interleukin-17 which is roinflammatory cytokine produced, although not exclusively, by T helper 17 recently identified as a distinct T helper lineage mediating tissue inflammation. Their study confirmsed the anti-inflammatory activity of polydatin and suggests a potential clinical relevance in the therapy of inflammatory diseases.
Antioxidant Properties
Like resveratrol, Polydatin is also famous for its antioxidant properties. There are lots of studies on its antioxidant properties, which showed its inhibitory action on peroxidation of linoleic acid (LA) and the radical scavenging ability towards different free radicals (such as DPPH) and radical initiators. It has been found that polydatin and resveratrol have similar antioxidant capacity, while the comparison with BHT (2,6-di-tert-butyl-4-methylphenol) and alpha-tocopherol (vitamin E, vit. E), taken as reference, points out a slower but prolonged protective action against lipid peroxidation. Furthermore, polydatin appears more efficacious than resveratrol as a consequence of the reaction of the latter with its radical form.
Cardiovascular Diseases Treatment
Polydatin is also beneficial for cardiovascular diseases treatment. According to one study in the year 2011, scientists concluded that polydatin exerted cardioprotective effect by the activation of PKC-KATP-dependent signaling and the direct anti-oxidative stress mechanisms through their experiments.
Polydatin Side effects
Polydatin might be safe for most adults. But there is not enough known about the use of mangosteen during pregnancy and breast-feeding.
Resveratrol Dosage
The appropriate dose of Polydatin depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for Polydatin. Consult your doctors before using.
Where to buy high quality Polydatin
Henan Steeda Industrial Co.,Ltd (Tiny Grass Botanicals Co.,Ltd) is a manufacturer of botanical extract and experienced supplier of Amino Acids & its Derivatives, Vitamins & its Derivatives, Sweeteners,  Minerals, Sports Nutrition, Nootropics and Cosmetic Ingredients. Giant Knotweed Powder Extract Polydatin is one of our most competitive products with stocks available all year round. By providing superior quality, we establish long-term relationships with our clients.

Our service:
1) Payment
We accept payments through Telex Transfer, PayPal, Western Union, Letter of Credit, MoneyGram.
2) Shipping method
We offer several delivery services to suit all customer needs, such as AIR freight, DHL, FEDEX, TNT, UPS, EMS, SEA freight and others.
3) Lead time
Usually orders can be dispatched within 3 workdays by courier; 15-30 workdays by Sea.
4) Guarantee
We offer a 60 Days 100% Risk Free Guarantee for any orders. We will refund your money if our products do not meet your requirements.

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